Recently, the low-emissivity glass has been used to reduce the energy loss through building windows. However, it simply reduces the inflow of solar rays and has a relatively high heat transmission coefficient. To solve the problems, a high-efficiency vacuum glazing has been under development but it has not been actively used due to its high price and insufficient performance. In this paper, the effects of internal pressure, pillar (spacer) height, pillar diameter, pillar interval, emissivity etc. on the performance of vacuum glazing have been analyzed with three-dimensional computational fluid dynamics and structural analysis. As a result, the performance of vacuum glazing was predicted more accurately and major factors that determine the performance of vacuum glazing were optimized.