Chrysin and chlorogenic acid are natural products derived from Scutellariae Radix and Lonicerae Flos, respectively. We examined whether chrysin and chlorogenic acid affect airway mucin production induced by TNF-${alpha}$ in NCI-H292 cells. Cells were pretreated with each agent for 30 min and then stimulated with TNF-${alpha}$ for 24 h. Of the two compounds, chrysin suppressed airway MUC5AC mucin production. Also, chrysin suppressed MUC5AC mucin gene expression and translocation of NF-${kappa}B$ p65 induced by TNF-${alpha}$. This result suggests that chrysin can regulate the production and gene expression of mucin induced by TNF-${alpha}$ through the inactivation of NF-${kappa}B$ in airway epithelial cells.