The aim of the research was to evaluate the incidence of breast cancer in the ecological areas of Kazakhstan and assess the potential. A retrospective study of 11 years (1999 to 2009) was conducted using descriptive and analytical methods. The incidence of breast cancer was the lowest in the Aral-Syr Darya area ($18.6{pm}0.80$/100,000), and highest in the Irtysh area ($48.9{pm}1.90$/100,000), with an increasing trends over time in almost all areas. A direct strong correlation between the degree of contamination with high pollution emissions in the atmosphere from stationary sources and the incidence of breast cancer ($r=0.77{pm}0.15$; p=0.026). The results indicate an increasing importance of breast cancer in Kazakhstan and an etiological role for environmental pollution.