MES (Manufacturing Execution System) is a powerful production management tool supporting production optimization from the process initiation to the final shipment. It not only transmits the production information to production planning systems like ERP (Enterprise Resource Planning) and SCM (Supply Chain Management) in real-time, but also orders the planned production data to the production site. It is a production management system which plans and executes based on the production data in the field, thus it must be operated with a data acquisition system which gathers the accurate field data in real-time. This study deployed the data acquisition system and HMI (Human Machine Interface) system to collect real-time equipment data through the interface with the equipment to develop MES, and the developed system was applied to the machine tool for verification of its effectiveness. The test indicated that the equipment operating time and other operating data of the equipment could be processed without the interference of the workers. The developed data acquisition system and HMI can be applied to other equipment by using different sensors.