This paper describes the influence of geometrical parameters on the hydrofoil performance in non-cavitating and cavitating flows. The two-phase incompressible Navier-Stokes solver is used to compute the hydrofoil performance in two operating conditions. The new hydrofoil useful for performance improvement is obtained through the optimization design with RSM and the application of nose-drooping geometry. In the optimization design with the response surface model between hydrofoil performance and hydrofoil geometry, it is observed that the design concept of maximum lift-to-drag ratio is appropriate for the improvement of hydrofoil performance. The application of nose-drooping design concept results in the increase of hydrofoil performance in non-cavitating and cavitating flows.