The functional significance of the proteasome activator $REG{gamma}$ in the regulation of cell proliferation and apoptosis has been recognized. However, pathological contributions to tumor development remain to be elucidated. Both oncogenic proteins and tumor suppressors are targeted by $REG{gamma}$ for proteasomal degradation. It has been proposed that the role of the $REG{gamma}$ in the pathogenesis of cancer is cell- and context-specific. In this study, we aimed to explore the potential involvement of $REG{gamma}$ in laryngeal carcinomas, comparing protein expression in tumor and adjacent tissues by immunohistochemical staining and Western blot analysis. We also characterized the correlation between the expression of $REG{gamma}$ and the previously identified substrates p53 and p21. We showed that $REG{gamma}$ was abnormally highly expressed in cancer tissues. Statistical analysis revealed that there was a positive relationship between the level of $REG{gamma}$ and the expression of p53 and p21. Our study suggests that $REG{gamma}$ overexpression can facilitate the growth of laryngeal cancer cells.