The droplet ejection behavior from drop-on-demand printhead are investigated numerically for Newtonian and shear-thinning fluid. The numerical simulation is performed using a volume-of-fluid model. In this study, we compare the printable range in terms of Z number and pinch-off time for Newtonian and shear-thinning fluids. The printability range are found to be 1.08 $$leq_-$$ Z $$leq_-$$ 12.9 for Newtonian fluid and 0.8 $$leq_-$$ Z $$leq_-$$ 12.9 for shear-thinning fluid. However, air entrainment is observed during merging of primary and satellite droplet within the printability range. The pinch-off time of the shear-thinning fluid is apparently shorter compared to the corresponding Newtonian fluid due to shear-thinning effects and the differences in the pinch-off time is enlarged significantly when the capillary number is larger than 0.5.