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A Transfer of Silver Nanoparticles from Pregnant Rat to Offspring
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  • A Transfer of Silver Nanoparticles from Pregnant Rat to Offspring
  • A Transfer of Silver Nanoparticles from Pregnant Rat to Offspring
저자명
Lee. Yeon-Jin,Choi. Jong-Hye,Kim. Pil-Je,Choi. Kyung-Hee,Kim. Su-Hyon,Shon. Woo-Chan,Park. Kwang-Sik
간행물명
Toxicological research
권/호정보
2012년|28권 3호|pp.139-141 (3 pages)
발행정보
한국독성학회
파일정보
정기간행물|ENG|
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기타
이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Silver nanoparticles (size: $7.9{pm}0.95$ nm, dosage: 250 mg/kg) were orally administered to pregnant rats. At 4 days after parturition, four pups were randomly selected (one pup from one dam) and silver level in liver, kidney, lung and brain was determined by ICP-MS and electron microscope. As results, silver nanoparticles highly accumulated in the tissues of the pups. Silver level in the treated group was $132.4{pm}43.9$ ng/g in the kidney (12.3 fold compared to control group), $37.3{pm}11.3$ ng/g in the liver (7.9 fold), $42.0{pm}8.6$ ng/g in the lung (5.9 fold), and $31.1{pm}4.3$ ng/g in the brain (5.4 fold). This result suggested that the possible transfer of silver nanoparticles from pregnant dams to the fetus through mainly placenta.