Purpose: In this paper, a Design for Six Sigma(DFSS) methodology based on DMADV(Define-Measure-Analyze-Design-Verify) roadmap is presented. Methods: DFSS tools are given for each DMADV phase which is suitable for the aircraft development process. A cost reduction case study of a navigation simulation is demonstrated. Results: DFSS roadmap are presented with implementation tools for each phase. Conclusion: We propose a DFSS methodology which can benefit the design and development personnel to implement DFSS not only in aircraft industry but also in other order-based industries in general.