The purpose of this study was to investigates the perception on medical technology, self-efficacy, and professional self conception of OR nurses. The data was collected by distributing structured questionnaires to 164 OR nurses in 13 secondary hospitals located in Gyeongsangnam-do and Gyeongsangbuk-do, beginning Apr. 12th to the 24th of 2010, and analyzed by t-test, ANOVA, Pearson correlation coefficient. The correlation between perception on medical technology and professional self conception showed to be positively correlated at r = .222. The correlation between self-efficacy and perception on medical technology showed positive correlation at r = .197. Also, the correlation between self-efficacy and professional self conception was r = .609, showing a relatively high positive correlation. We have observed that the perceptions of nurses on medical technology and their self efficacy have a significant effect in professional self consciousness. Therefore, it is important to develop programs that increase self-efficacy and followed by policies to maintain them.