The most important component of a nuclear power plant is its nuclear reactor. Studies on the integrity of reactors have become an important part regarding the safety of a nuclear power plant. The US Nuclear Regulatory Commission Regulatory Guide (NRC RG) 1.20 presents a Comprehensive Vibration Assessment Program (CVAP) to be used to verify the structural integrity of the Reactor Vessel Internals (RVI) for flow-induced vibration prior to commercial operation. However, there are few published studies related to the RVI CVAP. We classified the Advanced Power Reactor 1400 (APR1400) RVI CVAP as a non-prototype category-2 reactor as part of an independent validation of its design. The aim of this paper is to present the results of structural response analyses of the Upper Guide Structure (UGS) assembly of the APR1400 reactor. These results show that the UGS and the Inner Barrel Assembly (IBA) meet the specified integrity levels of the design acceptance criteria. The vibration and stress analysis results in this paper will be used as basic information to select measurement locations of the vibration and stress for the APR1400 RVI CVAP.