Dental caries is multifactorial local disease which involves destruction of the hard tissues of the teeth by metabolities produces by microorganisms. Recently, there has been growing interest in the role of nitric oxide (NO) and glutathione (GSH) in caries incidence. The aim of the study was to survey the studies reported the association among salivary NO, GSH and dental careis. Three studies reported the association between NO and dental caries. However, the results were contradictory. Only one study showed negative association between GSH and dental caries. In Korea, NO showed negative association with Lactobacilli and GSH showed positive association with dental caries. These observations suggest the possibility that NO and GSH could be new biomarkers for dental caries. However, further study should be needed.