In recent innovation trends, one notable feature is the merging and overlapping of technologies: in other words, technological convergence. A key technological convergence is the fusion of biotechnology (BT) and information technology (IT). Major IT advances have led to innovative devices that allow us to advance BT. However, the lack of data on IT-BT convergence is a major impediment: relatively little research has analyzed the inter-disciplinary relationship of different industries. We propose a systematic approach to analyzing the technological convergence of BT and IT. Patent analysis, including citation and co-classification analyses, was adopted as a main method to measure the convergence intensity and coverage, and two portfolio matrices were developed to manage the technological convergence. The contribution of this paper is that it provides practical evidences for IT-BT convergence, based on quantitative data and systematic processes. This has managerial implications for each sector of IT and BT.