The purpose of this study is to improve the cooling performance of single and cascade refrigeration systems using thermoelectric modules. The system consists of a heat sink, fan, and thermoelectric module. The operating parameters considered in this study include power distribution between the first- and second-stage thermoelectric modules, air flow, and variable condensing unit. The cooling capacity increased with decreases in the temperature difference between hot and cold surfaces, but decreased with increases in the condensing temperature. The COP decreased with increasing electric power of the thermoelectric module because of the increased Joule heat. The cooling performance improvement using the thermoelectric module is represented by the freezer temperature.