Generally, Sewage Treatment Plants(STPs) are complexes systems in which a range of physical, chemical and biological processes occur. However, their performance strongly depends on the know-how acquired by the field-engineer. Recently, in order to solve this situations, various operation and management technologies based on the Instrumentation, Control and Automation(ICA) have been developed. As a economies-environmental affect point of view, this study was for the performance evaluation and assessment of results from the Smart Operation System(SOS) in full-scale STP. The SOS in STP consisted of the process monitoring module, including real-time influent prediction and effluent simulation, and the Smart Air Control(SAC) module. According to the results from field test for 2 years, the results of economical evaluation, amount of benefits and cost saving by the SOS have shown to be much higher than that of traditional operation. Nevertheless, the removal load(kg/yr) of BOD 13.3 %, COD 28.2 %, TN 44.4 % and TP 20.8 % were increased, respectively. Remarkable improvement of removal load could be achieved after the SOS was adapted. It was concerned that the SOS offer a user friendly functionalities and cost saving needed by the field-engineers. In addition, it was expected that the results of this study would supply helpful information for design and cost saving for the SOS in full-scale STP.