Purpose: The purpose of this study was to examine the effects of aroma foot reflexology massage on mood states specifically depression and brain waves of elderly women with osteoarthritis. Methods: The study was a nonequivalent control group non-synchronized design. The participants were 62 elderly women with osteoarthritis. The instruments were the Korean-Profile of Mood States-Brief for mood states and 8-channel EEG (Electroencephalogram) system for brain waves. Data were collected from March to May, 2012. Twenty-six participants were assigned to the treatment group and twenty-six to the comparison group. The data were analyzed using SPSS/WIN 17.0 version program, and included descriptive statistics, t-test, and ANCOVA. The intervention was conducted three times a week for two weeks. Results: There were significantly improvement in reported depression. s. Brain waves (EEG) increased significantly in F3, T3 of ${alpha}$ wave and in F4, T3, and P4 of ${eta}$ wave between the two groups. Conclusion: Aroma foot reflexology massage can be utilized as an effective intervention to decrease depression of mood states, increase of ${alpha}$, and ${eta}$ brain wave on woman elderly with osteoarthritis.