Objectives: This study was performed to identify the relationship among sexual desire, other domains of sexual function and quality of life (QOL) and to describe the effect of sexual desire on sexual function and QOL in married women with hypoactive sexual desire disorder (HSDD). Methods: A total of 397 women with HSDD participated in this study. Data were collected through self-reported questionnaire which were constructed to include general characteristics items, Female Sexual Function Index (FSFI), and QOL tool. Data were analyzed using SPSS/WIN20 for descriptive statistics, t-test, one-way ANOVA, Duncan, partial correlation coefficients, and Hierarchial multiple regression. Results: There were significant correlations with sexual desire and other domains of sexual function. And also, sexual desire had a positive correlations with the psychological status and total QOL. The sexual desire was statistically significant predictors for sexual function and QOL. Conclusions: Health professionals should direct efforts toward developing sexual health-related counseling or education programs for women suffering from sexual dysfunction with the goal of helping them to achieve satisfying sex lives and improved quality of life.