We investigated the effect of red ginseng extracts on blood biochemical parameters, bone density and bone inorganic components etc. and data were analyzed by one-way ANOVA and Post-Hoc Test. In the results of our study, the level of albumin and HDL, Ca, P, Mg, and estradiol in blood, and the content of Ca, P, ash in femur were significantly increased in red ginseng treated group than in OVX group, and the level of ALP, AST, ALT, blood glucose, total cholesterol, triglyceride, LDL, creatinine, osteocalcin, and N-terminal telopeptide were significantly decreased in red ginseng treated group than in OVX group (p < 0.01). From these results, we knew that within the normal level, red ginseng extracts improved liver and kidney function, component of glucose and lipid in blood, bone density, bone ash and inorganic components in femur, and index related with bone metabolism.