To understand the relationship between various oceanographic factors and seaweed production, we examined the annual accumulated aquaculture production of Undaria pinnatifida with respect to water temperature, salinity, dissolved oxygen, current patterns and nutrients over 21 years (1990-2010) (this date range does not add up to over 21 years) along the coast of Busan, Korea. According to the results of the cross-correlation function, annual production of U. pinnatifida was closely related to the following conditions: low water temperature, low salinity, strong Tsushima Warm Current, and high concentrations of dissolved oxygen and nutrients. In this study, we also considered the Index of Oceanographic factors for U. pinnatifida (IOU) by computation of a simple equation. This index will be used for the prediction of U. pinnatifida aquaculture production off the coast of Busan.