Design optimization is a mathematical process to find an optimal solution through the use of formal optimization algorithms. Design plays a vital role in the engineering field; therefore, using design tools in education and research is becoming more and more important. Recently, numerical design optimization in fluid mechanics, which uses computational fluid dynamics (CFD), has numerous applications in the engineering field, because of the rapid development of high-performance computing resources. However, it is difficult to find design optimization software and contents for educational purposes in aerospace engineering. In the present study, we have developed an aerodynamic design framework specifically for an airfoil, based on the EDucation-research Integration through Simulation On the Net (EDISON) portal. The airfoil design framework is composed of three subparts: a geometry kernel, CFD flow analysis, and an optimization algorithm. Through a seamless interface among the subparts, an iterative design process is conducted. In addition, the CFD flow analysis and the design framework are provided through a web-based portal system, while the computation is taken care of by a supercomputing facility. In addition to the software development, educational contents are developed for lectures associated with design optimization in aerospace and mechanical engineering education programs. The software and content developed in this study is expected to be used as a tool for e-learning material, for education and research in universities.