Post-chlorination for disinfection in portable water process is final process. The design factors of post-chlorination are inflow pipe line from tank of filtrated water to cleanwell, injection point of chlorine, appropriate shape of baffle in cleanwell for disinfection efficient improvement. Until now, we did not have the design standard for post-chlorination. we evaluated most suitable design method of post-chlorination process in portable water process by using computational fluid dynamics in this research. We found the result that the pipe to connect the cleanwell should be one. If pipe line split into two or more, uniform distribution of the flow is difficult. Second, optimal injection point of chlorine is the middle of pipe line to connect the cleanwell. Therefore, it is not economical to install chlorine contact basin in cleanwell. Third, the shape of baffle should be designed in order to water flows in one direction. And we found that it is better to design the low number of flow turning.