Today, university students are suffering from various stresses such as individual capacity development, school score management, human relationships, job placement, and English study for preparation as member of society the future. However, stress of students decreases stabilization of mind and aggravate feeling of satisfaction of life. In this research, we examined the relationships among stress, mindfulness and life satisfaction among university students. In addition, we analyzed the moderating effect as university class levels on stress and life satisfaction using partial least squares. This results provide useful implications for decreasing stress, improving mindfulness, and increasing life satisfaction among university students.