Purpose. The purposed of this study was done to identify correlates and variables predicting burnout among hospital nurses. Methods. The participants were 172 nurses working in hospital nurses in D and P, K cities. Data on compassion fatigue and burnout were collected via questionnaire between May 2011 and July 2011. Data analysis was done with PASW 18.0 program and included one-way ANOVA, independent t-test, Pearson correlation, and stepwise multiple regression. Result. Compassion fatigue of participants in this study were shown to have high levels (compassion fatigue: M=58.34/115, SD=12.85). Burnout of participants in this study were shown to have poor levels (burnout: M=30.73/85, SD=6.84). The burnout by nurses was positively to compassion fatigue(r=.482, p<.000). The variables predicting burnout were compassion fatigue, total period of nursing job, nursing part and job period of present part. These factors accounted for 31%((F=20.39, p<.000) of the variance of burnout in hospital nurses. Conclusion. The results of this study indicate that it is necessary to reduce compassion fatigue and to encourage compassion satisfaction among hospital nurses.