Many practical processes in industry have nonlinearities of some forms. One commonly encountered form is actuator saturation which can cause a detrimental effect known as integrator windup. Therefore, a strategy of attenuating the effects of integrator windup is required to guarantee the stability and performance of the overall control system. In this paper, optimal tuning of a PID (Proportional-Integral-Derivative) controller with an anti-windup scheme is presented to enhance the tracking performance of the PID control system in the presence of the actuator saturation. First, we investigate effective anti-windup schemes. Then, the parameters of both the PID controller and the anti-windup scheme are optimally tuned by an EA (Evolutionary Algorithm) such as the IAE (Integral of Absolute Error) is minimized. A set of simulation works on two high-order processes demonstrates the benefit of the proposed method.