The purpose of this study is to investigate effects of White Ginseng-Ejung-tang (EG) and Red Ginseng-Ejung-tang (ER) water extract on production of various cytokines such as interleukin (IL)-21, IL-25, IL-$28{eta}$, erythropoietin (EPO), Exodus-2, monocyte chemotactic protein (MCP)-5, macrophage inflammatory protein (MIP)-$3{alpha}$, MIP-$3{eta}$, Fractalkine, and TARC in RAW 264.7 mouse macrophages stimulated by lipopolysaccharide (LPS). Levels of cytokines were measured by High-throughput multiplex bead array cytokine assay based on xMAP (multi-analyte profiling beads) technology. ER significantly decreased levels of IL-21, IL-25, IL-$28{eta}$, EPO, Exodus-2, MCP-5, MIP-$3{alpha}$, MIP-$3{eta}$, TARC, and fractalkine for 24 h incubation at the oncentrations of 25 and 100 ${mu}g/mL$ in LPS-induced RAW 264.7 (P < 0.05). But EG did not show any significant effect. These results suggest that ER has anti-inflammtory property related with its inhibition on the production of IL-21, IL-25, IL-$28{eta}$, and chemokines such as EPO, MCP-5, MIP-$3{alpha}$, MIP-$3{eta}$, Fractalkine, Exodus-2, and TARC in LPS-induced macrophages.