Purpose: This research was conducted to compare the effect of a wellness program on knowledge of obesity and weight loss in women schizophrenia inpatients. Methods: A nonequivalent control group pretest-posttest design was used for this study. A total of 44 patients with schizophrenia were randomly divided into an experimental group (22) and a control group (22) in a 12-week multimodal weight control program. For 6 weeks, the experimental group received approximately an hour of teaching on obesity interventions and for another 6 weeks one hour of teaching on exercise and weight control interventions while the control group received the usual care. The outcome variables were measured before and after the program. Data was analyzed with the ${chi}^2$-test and t-test using PASW Statistics 18. Results: For those who completed the weight control program, there was a mean weight loss of 1.37kg by the end of the intervention. The experimental group showed significant improvement in knowledge of obesity and weight loss. Conclusion: The wellness program was effective in reducing the weight of women schizophrenia patients as well as being effective in increasing knowledge of obesity. Therefore, nurses must consistently educate women schizophrenia inpatients about health care and knowledge of obesity.