A vision based hand-gesture interface method for substituting a pointing device is proposed in this paper, which is used the ratio and size variation of Gesture Region. Proposed method uses the skin hue&saturation of the hand region from the HSI color model to extract the hand region effectively. This method can remove the non-hand region, and reduces the noise effect by the light source. Also, as the computation quantity is reduced by detecting not the static hand-shape recognition, but the ratio and size variation of hand-moving from the clipped hand region in real time, more response speed is guaranteed. In order to evaluate the performance of the our proposed method, after applying to the computerized self visual acuity testing system as a pointing device. As a result, the proposed method showed the average 86% gesture recognition ratio and 87% coordinate moving recognition ratio.