Recently, the importance of the HVAC system (Heating, Ventilating and Air Conditioning System) is growing because comfortable working environment has emerged as important element for enhancing work efficiency. HVAC system is a general term of a system that collectively creates desired temperature and state through heating and air conditioning. HVAC system consists of many objects, so it requires a lot of constraints for its effective operation. Thus, specific strategy is needed for an optimal operation of HVAC System for plant. In this paper, manufacturing plants which have HVAC systems has been modeled and the objective function and constraints for an effective operation have been defined. And new strategy for an effective operation of HVAC system with energy simulations has been proposed.