The liquefaction process system is regarded as primary among all topside systems in LNG FPSO. This liquefaction process system is composed of many types of equipment. LNG equipment on offshore plants has quite different demands on the equipment compared to traditional onshore LNG plants, so the reliability analysis of this process system needs to be performed. This study investigates how DEVS formalism for discrete event simulation can be used to reliability analysis of the liquefaction cycle for LNG FPSO. The reliability analysis method based on DEVS formalism could be better model for reflecting the system configuration than the conventional reliability analysis methods, such as fault tree analysis and event tree analysis.