This study examined the relationship between spouse satisfaction and depressive symptom among the middle-aged and elderly couples, using dataset of the Korean Longitudinal Study of Ageing(KLoSA). The subjects were 6,652 persons aged 45 and over who were living with their spouse. A multiple regression model was used to study an association between spouse satisfaction and depressive symptom, controlling for socio-economic characteristics, health status and behavior, and social support. Also, this paper run three subgroup regression models based on age of subjects (45~54, 55~64, 65 and over), controlling for confounding variables. Authors found that there was negative relationship between spouse satisfaction and depressive symptom (b=-0.022, p<0.0001). This negative relationship was also shown in three subgroup regression models. This study suggested the importance of spouse support for promoting mental health among the middle-aged and elderly couples.