A numerical study was conducted to improve the performance of an impeller of centrifugal compressor. Nine design variables were chosen with constraints. Only meridional contours and blade profile were adjusted. ANN (Artificial Neural Net) was adopted as a main optimization algorithm with PSO (Particle Swarm Optimization) in order to reduce the optimization time. At first, ANN was learned and trained with the design variable sets which were obtained using DOE (Design of Experiment). This ANN was continuously improved its accuracy for each generation of which population was one hundred. New design variable set in each generation was selected using a non-gradient based method of PSO in order to obtain the global optimized result. After $7^{th}$ generation, the prediction difference of efficiency and pressure ratio between ANN and CFD was less than 0.6%. From more than 1,200 design variable sets, a pareto of efficiency versus pressure ratio was obtained and an optimized result was selected based on the multi-objective function. On this optimized impeller, the efficiency and pressure ratio were improved by 1% and 9.3%, respectively.