Objectives : To broaden understanding about meridian tendino-musculature acupuncture on headache and to evaluate the effect of meridian tendino-musculature acupuncture on headache. Methods and Results : From Feb. 2012 to Jan. 2013, the 64 patients were outpatients for treatment of headache in Department of Acupuncture and Moxibustion Medicine, Traditional Korean Medical Hospital, Semyung University and treated with meridian tendino-musculature acupuncture. To evaluate the effect of meridian tendino-musculature acupuncture, we devide 3groups(21 occipital-headache patients, 27 temporal-headache patients, 16 frontal-headache patients) upon pain area and search pain intensity(VAS were used), different frequency, duration time. As a result, headache are improved remarkably within two weeks. Conclusions : Meridian tendino-musculature acupuncture was found to be helpful to patients who wish to recover from headache. In order to make this meridian tendino-musculature acupuncture more available, we should pay more attention to improving treatment appliance and acupuncture techniwue.