Objectives : This study was to evaluate the effectiveness of manipulation complex therapy on ankle sprain with ankle pain. Methods : We divided ankle sprain with ankle pain patient into 2 groups; one group combined manipulation therapy and acupuncture therapy, another group was only acupuncture therapy. To estimate the efficacy of treatment that applied for two groups, we used visual analog scale(VAS) and ankle-hindfoot scale(AHS). We compared the VAS score and AHS score of two groups statistically. Results : 1. As a result of evaluation by using visual analog scale(VAS) and ankle-hindfoot scale(AHS), treatment score at final was marked more higher than score before treatment on each groups. 2. treatment at final, acupuncture and manipulation therapy group had significant result on visual analog scale(VAS) and ankle-hindfoot scale(AHS) compared with acupuncture therapy group. Conclusions : Manipulation therapy can be used with acupuncture therapy for highly effective treatment for ankle sprain with ankle pain.