Purpose: The purpose of this research was to develop and evaluate the effects of an empowerment program. Method: We developed an 8-week empowerment program to decrease cancer symptoms and increase self-efficacy, self-esteem, and empowerment. This program includes aspects concerning self-knowledge and management, self-help groups, self-advocacy, resource network, and laughter therapy. We evaluated the effects of this program on 32 home-based cancer patients (one group pretest-posttest design). The data collection was performed from August 22, 2011 to October 13, 2011. Data were analyzed using the SPSS/WIN 18.0 program. Result: There were significant differences in self-esteem derived from the empowerment program. However, there were no significant differences in cancer symptoms, self-efficacy, and empowerment after the program. Conclusion: More research, using a control group pretest-posttest design that considers an appropriate intervention duration, is needed to more accurately examine the effects of the program. We expect this intervention to improve the empowerment of home-based cancer patients.