Weight reduction of a automobile has been steadily tried in automotive industry to improve fuel efficiency, driving performance and the production profits. Since the weight of BIW takes up a large portion of the total weight of the automobile, reducing the weight of BIW greatly contributes to reducing the total weight of the vehicle. To reduce weight, vehicle manufacturers have tried to apply lightweight materials, such as aluminum and high-strength steel, to the components of BIW instead of conventional steel. In this research, material arrangement of an automotive BIW was optimized by formulating a design problem to minimize weight of the BIW while satisfying design requirements about bending and torsional stiffness and perform a metamodel-based design optimization strategy. As a result of the design optimization, weight of the BIW is reduced by 45.7% while satisfying all design requirements.