In this paper, a new approach for cable layout design of pre-stressed concrete slabs is presented. To account the cable profile accurately, it is modelled by B-spline. Using the convex hull property of the B-spline, an efficient algorithm has been developed to obtain the cable layout for pre-stressed concrete slabs. For finite element computations, tendon and concrete are modelled by 3 noded bar and 20 noded brick elements respectively. The cable concrete interactions are precisely accounted using vector calculus formulae. Using the proposed technique a two way prestressed concrete slab has been successfully designed considering several design criteria.