One of the major benefits of the pre-stressed concrete pavements is the omission of tension in concrete that results in a reduction of cracks in the concrete slabs. Therefore, the life of the pavement is increased as the thickness of the slabs is reduced. One of the most important issues in dealing with the prestressed concrete pavement is determination of the magnitude of the pre-stress. Three dimensional finite element analyses are conducted in this research to study the pre-stress under various load (Boeing 777) and thermal gradient combinations. The model was also analyzed under temperature gradients without the presence of traffic loading and the induced stresses were compared with those from theoretical relationships. It was seen that the theoretical relationships result in conservative values for the stress.