Earthquake response calculation, parametric analysis and seismic parameter optimization of base-isolated structures are some critical issues for seismic design of base-isolated structures. To calculate the earthquake responses for such non-symmetric and non-classical damping linear systems and to implement the earthquake resistant design codes, a modified complex mode superposition design response spectrum method is put forward. Furthermore, to do parameter optimization for base-isolation structures, a graphical approach is proposed by analyzing the relationship between the base shear ratio of a seismic base-isolation floor to non-seismic base-isolation one and frequency ratio-damping ratio, as well as the relationship between the seismic base-isolation floor displacement and frequency ratio-damping ratio. In addition, the influences of mode number and site classification on the seismic base-isolation structure and corresponding optimum parameters are investigated. It is demonstrated that the modified complex mode superposition design response spectrum method is more precise and more convenient to engineering applications for utilizing the damping reduction factors and the design response spectrum, and the proposed graphical approach for parameter optimization of seismic base-isolation structures is compendious and feasible.