This paper describes the design optimization of Unmanned Aerial Vehicles(UAVs). An optimization framework has been developed and implemented for the conceptual design of UAVs. An integrated design analysis program was developed with several analysis modules such as propulsion, performance, mission, weight, and stability and control. A UAV configuration design optimization was performed by implementing the integrated analysis to enhance the endurance of UAVs. A SQP optimizer was utilized to build an optimization module for this program and sensitivity analysis was performed to determine the trends of shape variables for developing optimization objective. In conclusion, the results indicate that the resulting optimized UAVs configurations show performance improvements over the baseline design and reliable analysis results.