Objectives : The aim of this study is to analyze the research trend focusing on well-being studies in Korea. Through this study, the researchers attempt to explore the research trends of the Yangseng(養生) and well-being in Traditional Korean Medicine. Methods : Well-being as a key word was searched on representative domestic databases of articles. The researchers collected the articles of journals published from 1980 to 2012. Finally 2,413 articles of well-being were selected. Results : Domestic studies of well-being had been increased steadily since the 1990s and they were greatly increased after the 2000s boom of well-being. Before 2000s, the mainstream of well-being studies was to analyse the correlation among the variables associated with quality of life in medicine. After the boom of well-being, the number of researches has been increasing significantly, since 2000s. Various methodologies of well-being studies(especially related various goods and services) have also been developed in the field of academia. Recently the concept of well-being has been evolving into LOHAS, wellness, healing, well-dying and etc. Conclusions : In order to handle the new wave of society and medicine, new health concept of Traditional Korean Medicine should be developed through Korean unique ideas of Yangseng.