Objectives : The aim of this study is to analyze the domestic research trend focusing on well-being studies in medicine. Through this study, the researchers attempt to explore the research trends of the well-being in Traditional Korean Medicine. Methods : Well-being as a key word was searched on representative domestic databases of articles and the researchers collected the articles of medical journals published from 1980 to 2012. Finally 416 articles of well-being were selected. Results : Among the fields of medicine, well-being studies have been mainly proceeded by nursing science, preventive medicine and psychiatry. Well-being studies that mainly analyzed the variables associated wih quality of life and well-being to cancer patients, workers and elderly. But every measuring instrument searched with well-being was adapted from western tools. And there has not been any study used measuring instrument of well-being and interventions related to Traditional Korean Medicine. Conclusions : In order to handle the new wave of well-being and quality of life, research methods using tools to measure these variables need to be developed. Furthermore, it seems to be necessary that research on how to take advantage of Yangseng that is health concept of Traditional Korean Medicine.