The relationship between composition and properties of enamel glass was investigated by introducing a mixture design. The enamel glass was manufactured by mixing various components under the following constraints: $45{leq}SiO_2{leq}55$, $10{leq}B_2O_3{leq}18$, $6{leq}Na_2O{leq}15$, $1{leq}Li_2O{leq}6$, $5{leq}K_2O{leq}10$, $0{leq}TiO_2{leq}8$, $0{leq}ZrO_2{leq}8$, 13.3MO (mol %). A mathematical model for the calculation of some properties of enamel glasses as a function of their composition was developed by the experimental statistical method. The results showed that the proposed model with the experimental measurement were in good agreement and the mixture experimental design was an effective method for optimizing the composition of the enamel glass with respect to its properties.