The purpose of a micro-mixing device is to enhance the mixing by increasing the diffusion effect between different types of flows. There have been many attempts to actively or passively increase mixing. However, those studies were limited to lab-scale experiments because the production of devices requires a series of processes, time, cost, and the mixing quality itself. For this reason, this study attempted to develop a quick and simple process for micro-mixing device fabrication by using conventional machining and bonding processes and applying ultrasonic waves from the outside of the mixing device. The mixing quality was quantified by using the mixing index, and the results showed that the proposed system increases the mixing from ~33% to ~10% with respect to the flow rates.