Phospholipid polymer having zwitterion polar group and cell membrane structure is known as highly biocompatible and its functionality of skin care effect was already verified. In this study, new biocompatible multi-functional textile finishing agents based on phospholipid 2-methacryloyloxyethyl phosphorylcholine (MPCE) copolymer was developed and applied to polyesters to characterize the functionalities of the finishing agents. Also the biocompatibilities and skin care properties of the MPCE finishing agents were confirmed by single-dose patch test and skin barrier function recovery test.