An analytical investigation on the performance of adsorption-compression hybrid refrigeration systems with two different cycle configurations, cascade type and subcool type has been performed. In the former type, a cascade condenser is used which works as a condenser for mechanical compression cycle and evaporator for adsorption cycle. In the latter type, an evaporative subcooler is used which subcool the fluid of mechanical compression cycle. The refrigerants examined for the mechanical compression cycle are R134a, R152a, R1234yf and R1234ze whereas ethanol is the refrigerant for the adsorption cycle. The main feature of the proposed system is the capability to significantly reduce work input for the mechanical compressor which results up to 30% energy saving potential depending on the selection of refrigerant and system configuration. Based on the thermodynamic properties and laws the study analyzed the effect of the major design parameters such as evaporation temperature, compressor discharge pressure and desorption temperature on the system performances.