In this paper, second law analysis has been done for the vapor compression-vapor absorption (VC-VA) cascade system. Ammonia-water is considered as the working pair in absorption section and R407C is dealt as the working fluid in VC section. Exergy destruction or the irreversibility rate is determined in each components of VC-VA cascade system, for a wide range of cooling capacity by considering a variable speed reciprocating compressor. Further in this, Coefficient of structural bond (CSB) analysis is carried out to quantify the effect of varying the generator temperature, effectiveness of solution heat exchanger, inlet temperature of external fluids in evaporator/condenser and some other variables. Solution heat exchanger and the condenser are reported to have high CSB value, so have a great scope of improvement to reduce the irreversibility rate of the whole system.