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Inference of kinship coefficients from Korean SNP genotyping data
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  • Inference of kinship coefficients from Korean SNP genotyping data
  • Inference of kinship coefficients from Korean SNP genotyping data
저자명
Park. Seong-Jin,Yang. Jin Ok,Kim. Sang Cheol,Kwon. Jekeun,Lee. Sanghyuk,Lee. Byungwook
간행물명
BMB reports
권/호정보
2013년|46권 6호|pp.305-309 (5 pages)
발행정보
생화학분자생물학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
서지반출

기타언어초록

The determination of relatedness between individuals in a family is crucial in analysis of common complex diseases. We present a method to infer close inter-familial relationships based on SNP genotyping data and provide the relationship coefficient of kinship in Korean families. We obtained blood samples from 43 Korean individuals in two families. SNP data was obtained using the Affymetrix Genome-wide Human SNP array 6.0 and the Illumina Human 1M-Duo chip. To measure the kinship coefficient with the SNP genotyping data, we considered all possible pairs of individuals in each family. The genetic distance between two individuals in a pair was determined using the allele sharing distance method. The results show that genetic distance is proportional to the kinship coefficient and that a close degree of kinship can be confirmed with SNP genotyping data. This study represents the first attempt to identify the genetic distance between very closely related individuals.