Most yacht sails are made of thin fabric, and they have a cambered shape to generate lift force; however, their shape can be easily deformed by wind pressure. Deformation of the sail shape changes the flow characteristics over the sail, which in turn further deforms the sail shape. Therefore, fluid-structure interaction (FSI) analysis is applied for the precise evaluation or optimization of the sail design. In this study, fluid flow analyses are performed for the main sail of a 30-foot yacht, and the results are applied to loading conditions for structural analyses. By applying the supporting forces from the rig, such as the mast and boom-end outhaul, as boundary conditions for structural analysis, the deformed sail shape is identified. Both the flow analyses and the structural analyses are iteratively carried out for the deformed sail shape. A comparison of the flow characteristics and surface pressures over the deformed sail shape with those over the initial shape shows that a considerable difference exists between the two and that FSI analysis is suitable for application to sail design.