Purpose: The purpose of this study was to compare reported physical symptoms, hope and family support of cancer patients between general hospitals and long-term care hospitals. Methods: Subjects were 175 patients diagnosed with cancers from two general hospitals and six long-term care hospitals located in G city. Subjects completed a questionnaire with questions about general characteristics and questions about the disease, physical symptoms, hope and family support. Data was collected from February to April and the data were analyzed using an independent t-test and one-way ANOVA. Results: The subjects in long-term care hospitals showed higher percentage in pain, nausea, fatigue, sleep disorder, and change in appearance. There was a significant difference in family support between two groups. A significant positive correlation was found between hope and family support in subjects in general and long-term care hospitals. Conclusion: Significant differences were found in some physical symptoms and family support between cancer patients in general hospitals and long-term care hospitals. Thus, nurses in long-term care hospitals need provide care suitable for the characteristics of cancer patients in long-term care hospitals.