Track irregularities is one of the key factors influencing the running behavior of trains. In order to ensure safety and ride comfort of train, the criteria for track irregularities should be adequately established regarding vehicle velocity, vehicle characteristics, characteristics of the track recording car, and measurement interval. Also, track maintenance should be carried out thoroughly according to the criteria for managing track irregularities. Numerical analysis was conducted to investigate the influence of track alignment on the running behavior of Korean high speed train(KTX). Various wavelengths and amplitudes of lateral alignment were considered as parameters for this study using the Vampire program, a vehicle dynamics modeling package in railway environment. Derailment, lateral load, bogie acceleration and body acceleration of numerical analysis results due to alignment were investigated. Finally, the influence of the alignment on safety and ride comfort for the KTX was evaluated. This study indicates that alignment irregularities have significant impacts on running safety, and that the criteria used to manage alignment irregularities should be restrictive to ensure the running safety of the KTX.